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“Our aim is to grasp female reproductive aging, and why fertility rapidly declines starting inside the mid-30s,” states Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata works.
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“If we know how this chromatin state is set up, And just how it pertains to oocyte excellent, it could finally produce therapies for a few types of infertility,” says Namekawa.
Using the GCRLE grant, Munakata and Namekawa will seem additional closely at how oocytes are genomically primed and stored for afterwards use. They can investigate the part of a chromatin remodeler in oocyte survival and fertility.
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This could enable describe why more mature Ladies are more likely to bear small children with chromosomal Problems like Down Syndrome, during which an extra copy of chromosome 21 finds its way into an oocyte — and later on, an embryo.
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